Cardiovascular agents, anti obese agents, anti diabetic agents, anti cancer agents, immune boosters, substances that manage chronic inflammatory disorders and formulations to cure degenerative diseases. Boerhavia diffusa herb uses, benefits, cures, side effects. Nyctaginaceae and its adulterant plants 435 table i boerhaavia diffusa are differentiated on the basis of following morphological characters boerhaavia diffusa l. Asian journal of biochemical and pharmaceutical research evaluation of hepatoprotective efficacy of polyherbal formulation amlycure ds on anti tubercular drug induced hepatotoxicity anil kumar. The aim of the present study was to determine the anti diabetic activity of a polyherbal formulation in streptozotocin induced type 2 diabetic rats.
Formulation and evaluation of antiseptic polyherbal ointment. Results of short term stability study were also found to be satisfactory and were comparable to initial formulation. All the formulations showed predominant activity against selected species. The study focuses on polyherbal antidiabetic formulations of different plants used in the treatment of diabetes mixed in different concentrations. An overview on anti diabetic activity of siddha medicinal plants. Boerhaavia diffusa supplement health benefits, dosage. The boerhaavia diffusa plant contains a large number of such compounds as flavonoids, alkaloids, steroids. Rats were randomly divided into 6 groups containing 8 rat in each group. Boerhaavia diffusa is a tropical crawling root plant, with bioactive compounds in both.
Asian journal of biochemical and pharmaceutical research 2015 coden issn. Anti arthritic evaluation of ddifferent extracts of boerhaavia diffusa linn. Stress was induced by subjecting animals to cold restraint. Uses, benefits, cures, side effects, nutrients in boerhavia diffusa. Pharmacological properties of boerhavia diffusa international. The present study was aimed to evaluate the anti diabetic activity potential of boerhaavia diffusa roots against streptozotocin induced experimental rats. Use as a single drug and use of more than one drugs, in which the latter is known as phf.
Pdf effect of chronic administration of boerhavia diffusa linn. Hydroethanolic extract 80% of boerhaavia diffusa hebd and a polyherbal formulation punarnava mandur phf09 containing boerhaavia diffusa were compared for their antistress activity using cold restraint stress model. Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver toxicity in mice. The adaptogenic activity of boerhavia diffusa extract is due to flavonoids. The polyherbal formulation nrkft and authenticated whole plant of boerhaavia diffusa family.
Herbal formulation was prepared with the mixture of. Phytochemical, therapeutic, and ethnopharmacological. The hydroalcoholic extracts of eugenia jambolana, gymnema sylvestre, momordica charantia and andrographis paniculata and sodhana processed extract of myristica fragrans were prepared. Hence, the prepared polyherbal formulation f9 can be used as a stable, patient compliant and cost effective solid dosage form. This paper explains the evidencebased information regarding the pharmacological activity of this plant. Antidiabetic activity of boerhaavia diffusa l effect on hepatic key. In the present study eleven medicinal plants with proven antidiabetic and related beneficial effects were selected for the preparation of five mixtures. Rjpt pharmacological activities of boerhaavia diffusa.
Chemotherapeutic potential of boerhaavia diffusa linn. Formulation and anti diabetic activity studies of herbomineral formulation for treatment of diabetes. Research article polyherbal formulations for anti diabetic therapy h. Asian journal of pharmaceutical and clinical research. Drug formulation in ayurveda is based on two principles. Rjpt antidiabetic potential of a traditional polyherbal. Antidiabetic activity of a polyherbal formulation drfay. Many herbs and spices are known to be antihyperglycemic. Review plant kingdom nutraceuticals for diabetesarticle. Polyherbal formulations based on indian medicinal plants as. Kaur, anti convulsant activity of boerhaavia diffusa. In different areas of the world, boerhaavia diffusa has also been used for pain relief, anti inflammation, and treating indigestion. There was significant reduction in total cholesterol, ldl cholesterol, vldl cholesterol and improvement in hdl cholesterol in diabetic rats. The present study was an attempt to conform the anti diabetic potential of the same, were in we have used streptozotocin induced type 2 diabetic model.
The present study was designed to investigate the antihyperlipidemic activity of an aqueous extract of boerhavia diffusa leaves in alloxan diabetic rats. Historically, boerhaavia diffusa has been used for its anti diabetic and diuretic properties. Comparative study on morphoanatomy of leaf, stem and root. The animals of diabetic control showed significant increase in serum tgl, total cholesterol and ldl while increase in hdl when compared with normal animals. The study proved that the active anti nociceptive principle of b. Diabetes mellitus, polyherbal, sodium starch glycolate, crosspovidone. Further, polyherbal formulations were evaluated for its anti bacterial activity against staphylococcus aureus, pseudomonas sp. The alcoholic extracts of tribulus terrrestris fruits and boerhaavia diffusa roots as shown significant activity on comparison to the synthetic drug spironolactone, poly herbal formulation cystone and to the other extracts of the drug, the furosemide was found to non active on formed crystals.
Boerhavia diffusa an overview sciencedirect topics. Nyctaginaceae was obtained as a gift sample from aimil pharmaceutical india limited, new delhi. Polyherbal formulations based on indian medicinal plants. Review on nephroprotective activity study by different plant extract paoulomi chatterjee 1. Hydroethanolic extract 80% of boerhaavia diffusa hebd and a polyherbal formulation punarnava mandur phf. Several researchers have confirmed biological, pharmacological and clinical activities of the plant and its phyto constituents. Antidiabetic activity of a polyherbal formulation diab et. Request pdf antidiabetic activity of boerhaavia diffusa l effect on hepatic key. Asian journal of biochemical and pharmaceutical research. Group i and ii served as normal and diabetic control respectively and received vehicle 1 mlkg, po.
Antidiabetic activity of boerhaavia diffusa l effect on hepatic key enzymes in experimental diabetes. The mechanism of its analgesic effect was not known. Boerhaavia diffusa belonging to family nyctaginaceae has a wide distribution, occurring on major part of the globe. Some of the promising effects of this plant include diuretic, hepatoprotective, anti inflammatory, anti fibrinolytic, anti cancer, anti diabetic, immunomodulatory, immunosuppressive, anti. Formulation development and evaluation of antidiabetic. Unlike a single chemical entity that forms the basis of conventional medicine, traditional ayurvedic medicine views the polyherbal preparations as they induce combined therapeutic activity. In order to ensure correct botanical standardization to remove the controversy, a detailed pharmacognostic study on whole plant of solanum nigrum linn has been. Antidiabetic activity of polyherbal formulation on. With this background, the present research work was undertaken to standardize and evaluate antidiabetic and antihyperlipidemic activities of a polyherbal formulation, ojamin, using streptozotocin stzinduced diabetic model in rats. An inhibition of nk cell activity has been noted with an ethanolic extract of the herb, yet further testing failed to find any influence from eupalitin or its glycoside. This key traditional therapeutic herbal strategy exploits the combining of several medicinal herbs to achieve extra therapeutic effectiveness, usually known as polypharmacy or polyherbalism.
Liv52 has been in the market for half a century and is widely marketed in india for the therapy of chronic liver diseases. Design and development of a stable polyherbal formulation. Antidiabetic activity of polyherbal formulation in streptozotocin ncbi. The extract antidiabetic activity was comparable to that of the antidiabetic drug glibenclamide. Group iii and iv were treated orally with drfay5001 300 and 600 mgkg, respectively. Antidiabetic activity of polyherbal formulation 601 into 5 groups of 6 rats each. Numerous plants and polyherbal formulations are used for the treatment of renal diseases. The efficacy of prepared mixtures has been tested on streptozotocin stz induced diabetic. Effect of polyherbal mixtures on the treatment of diabetes. Phytochemical and biological importance of boerhavia. Punarnava mandur contains boerhaavia diffusa, mandur bhasm, varun, bharangi. P,india,2 departmentbarkatullah university, 3 drug technology, faculty of medical technology derna, libya received.
Evaluation of antidiabetic activity of a herbal formulation. It is being sold in the market under the common name makoy. Antistress activity of boerhaavia diffusa root extract and a polyherbal formulation, containing boerhaavia diffusa using cold restraint stress model. The blood glucose lowering activity of the polyherbal preparation 1and 2 was studied in normal rats and alloxaninduced diabetic rats after oral administration at doses of 1. Furthermore, the study investigated effect of simultaneous administration of oj and metformin in diabetic rats. Antidiabetic, antihyperlipidemic activities and herbdrug. The diabetic animals were randomly divided into eight groups with 8 rats in each group and treated as follows for 14 days continuously orally. The root and aerial parts of boerhaavia diffusa linn.
Comparative study on morphoanatomy of leaf, stem and root of boerhaavia diusa l. Evaluation of anti diabetic activity of the polyherbal formulation 16. Boerhaavia diffusa is an herb found in ayurveda and other traditional medicines. Polyherbal formulation for kidney and liver protection international. The whole plant or its specific parts leaves, stem, and roots are known to have medicinal properties and have a long history of. Pdf boerhaavia diffusa is one of the renowned medicinal plants used to treat large number of human ailments as mentioned in ayurveda, charaka samhita. Antidiabetic activity of a polyherbal formulation in. Antidiabetic, antihyperlipidemic activities and herbdrug interaction of a polyherbal formulation in streptozotocin induced diabetic rats.
Detail study on boerhaavia diffusa plant for its medicinal. List of various diseases cured by boerhavia diffusa. How boerhavia diffusa is effective for various diseases is listed in repertory format. Kakamachi solanum nigrum linn belongs to family solanaceae and is being used in ayurveda in skin diseases and diabetes. Pdf detail study on boerhaavia diffusa plant for its. Vishnu p choudhari maeers maharashtra institute of pharmacy, mit campus, paud road, kothrud, pune, maharashtra 411038, india. Comparative screening of polyherbal preparations for anti diabetic and antioxidant activity in rats. In the present study the antihyperglycemic, hypolipidemic and antioxidant properties of newlinethe specially formulate polyherbal formulation in streptozotocin induced diabetic rats newlinewas determined. Habit erectdiffuse branched herbs glabrous, pubescent, diffuse. Boerhaavia diffusa from traditional use to scientific.
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